PLC Publications and Research

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Princeton Longevity Center’s physicians are leaders in preventive medicine and cardiac imaging.  Princeton Longevity Center Physicians frequently lecture around the world and have trained hundreds of cardiologists and radiologists in our renowned Cardiac CT Imaging courses.

Below, we are proud to offer a sampling of some of their recent research and publications in major medical journals.

In Reply-Revisiting the Historical Origins of Clinically Meaningful Coronary Artery Obstruction.
Rumberger JA.M ayo Clin Proc. 2017 Aug;92(8):1312-1313. doi: 10.1016/j.mayocp.2017.05.020. No abstract available.PMID:2877826

 

Clinical indications for coronary artery calcium scoring in asymptomatic patients: Expert consensus statement from the Society of Cardiovascular Computed Tomography.Hecht H, Blaha MJ, Berman DS, Nasir K, Budoff M, Leipsic J, Blankstein R, Narula J, Rumberger J, Shaw LJ. J Cardiovasc Comput Tomogr. 2017 Mar – Apr;11(2):157-168. doi: 10.1016/j.jcct.2017.02.010. Epub 2017 Feb 24. Review.

 

Worksite Nutrition: Is a Nutrient-Dense Diet the Answer for a Healthier Workforce?
Sutliffe J. Scheid J. Gorman M, Adams A, Carnot MJ, Wetzel W, Fortin T, Sutliffe C, Fuhrman J.  American Journal of Lifestyle Medicine. Published online April 9, 2018.

The Hidden Dangers of Fast and Processed Food.
Fuhrman J.   American Journal of Lifestyle Medicine, April 2018, SAGE Publishing. DOI: 10.1177/1559827618766483
*Condensed and adapted from Fast Food Genocide (HarperCollins 2017) for a lecture given at the ACLM annual conference Tuscan, Arizona, October 2017.

Coronary Artery Disease: A Continuum, Not a Threshold.
Rumberger JA
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Mayo Clin Proc. 2017 Mar;92(3):323-326. doi: 10.1016/j.mayocp.2017.01.009. No abstract available.

Rationale and design of the coronary artery calcium consortium: A multicenter cohort study.
Blaha MJ, Whelton SP, Al Rifai M, Dardari ZA, Shaw LJ, Al-Mallah MH, Matsushita K, Rumberger JA, Berman DS, Budoff MJ, Miedema MD, Nasir K.
J Cardiovasc Comput Tomogr. 2017 Jan – Feb;11(1):54-61. doi: 10.1016/j.jcct.2016.11.004.

Nutrient-dense, Plant-rich Dietary Intervention Effective at Reducing Cardiovascular Disease Risk Factors for Worksites: A Pilot Study. Sutliffe JT, Fuhrman J, Carnot MJ, Beetham R  Alternative Therapies. Sept/Oct 2016;22(5):32-36.

Randomized, double-blind, placebo-controlled, clinical study on the effect of Diabetinol(®) on glycemic control of subjects with impaired fasting glucose.
E
vans M, Judy WV, Wilson D, Rumberger JA, Guthrie N.
Diabetes Metab Syndr Obes. 2015 Jun 25;8:275-86. doi: 10.2147/DMSO.S79450. eCollection 2015.

Improved Cardiovascular Parameter With a Nutrient-Dense, Plant-Rich Diet-Style: A Patient Survey With Illustrative Cases.
Fuhrman J, Singer M  American Journal of Lifestyle Medicine. 1559827615611024. October 15, 2015 doi:10.1177/1559827615611024.

Traditional cardiovascular disease risk factors associated with one-year all-cause mortality among those with coronary artery calcium scores ≥400.
Al Rifai M, McEvoy JW, Nasir K, Rumberger J, Feldman D, Budoff MJ, Blaha MJ. Atherosclerosis. 2015 Aug;241(2):495-

Usefulness of regional distribution of coronary artery calcium to improve the prediction of all-cause mortality.
Tota-Maharaj R, Joshi PH, Budoff MJ, Whelton S, Zeb I, Rumberger J, Al-Mallah M, Blumenthal RS, Nasir K, Blaha MJ. Am J Cardiol. 2015 May 1;115(9):1229-34.

Dietary Protocols to Maximize Disease Reversal and Long Term Safety. American Journal of Lifestyle Medicine.
Fuhrman J.  May 4, 2015 doi:10.1177/1559827615580971

Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation.
Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T.Vasc Health Risk Manag. 2014 Feb 27;10:89-100

All-cause mortality in asymptomatic persons with extensive Agatston scores above 1000.
Patel J, Blaha MJ, McEvoy JW, Qadir S, Tota-Maharaj R, Shaw LJ, Rumberger JA, Callister TQ, Berman DS, Min JK, Raggi P, Agatston AA, Blumenthal RS, Budoff MJ, Nasir K. J Cardiovasc Comput Tomogr. 2014 Jan-Feb;8(1):26-32

Telaprevir in the treatment of acute hepatitis C virus infection in HIV-infected men.
Fierer DS, Dieterich DT, Mullen MP, Branch AD, Uriel AJ, Carriero DC, van Seggelen WO, Hijdra RM, Cassagnol DG; Paolino C, New York Acute Hepatitis C Surveillance Network. Clin Infect Dis. 2014 Mar;58(6):873-9. doi: 10.1093/cid/cit799. Epub 2013 Dec 13.

Impact of coronary artery calcification on all-cause mortality in individuals with and without hypertension.
Graham G, Blaha MJ, Budoff MJ, Rivera JJ, Agatston A, Raggi P, Shaw LJ, Berman D, Rana JS, Callister T, Rumberger JA, Min J, Blumenthal RS, Nasir K. Atherosclerosis. 2012 Dec;225(2):432-7.

Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification.
McEvoy JW, Blaha MJ, Rivera JJ, Budoff MJ, Khan AN, Shaw LJ, Berman DS, Raggi P, Min JK, Rumberger JA, Callister TQ, Blumenthal RS, Nasir K. JACC Cardiovasc Imaging. 2012 Oct;5(10):1037-45

CT defined atherosclerotic plaque type and severity: using the results of the diagnostic microscope to sharpen the clarity of peering through the prognostic telescope.
Rumberger JA. JACC Cardiovasc Imaging. 2012 Oct;5(10):1000-2

Coronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years old.
Tota-Maharaj R, Blaha MJ, McEvoy JW, Blumenthal RS, Muse ED, Budoff MJ, Shaw LJ, Berman DS, Rana JS, Rumberger J, Callister T, Rivera J, Agatston A, Nasir K.Eur Heart J. 2012 Jul 26

Interplay of coronary artery calcification and traditional risk factors for the prediction of all-cause mortality in asymptomatic individuals.
Nasir K, Rubin J, Blaha MJ, Shaw LJ, Blankstein R, Rivera JJ, Khan AN, Berman D, Raggi P, Callister T, Rumberger JA, Min J, Jones SR, Blumenthal RS, Budoff MJ.Circ Cardiovasc Imaging. 2012 Jul 1;5(4):467-73.

Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes.
Silverman MG, Blaha MJ, Budoff MJ, Rivera JJ, Raggi P, Shaw LJ, Berman D, Callister T, Rumberger JA, Rana JS, Blumenthal RS, Nasir K. Diabetes Care. 2012 Mar;35(3):624-6.

Glycemic and cardiovascular parameters improved in Type 2 Diabetes with the high nutrient density (HND) diet.
Dunaief DM, Fuhrman J, Dunaief JL, Ying G.   Open Journal of Preventive Medicine. 2012 Aug;2(3):364-371

Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.
Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M.Nutr Res. 2011 Aug;31(8):608-15.

Training, competency, and certification in cardiac CT: a summary statement from the Society of Cardiovascular Computed Tomography.
Pelberg R, Budoff M, Goraya T, Keevil J, Lesser J, Litwin S, Newton C, Ridner M, Rumberger J, Teague S, Winkler M; Society of Cardiovascular Computed Tomography.J Cardiovasc Comput Tomogr. 2011 Sep-Oct;5(5):279-85. Epub 2011 Aug

Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
Shen H, Damcott CM, Rampersaud E, Pollin TI, Horenstein RB, McArdle PF, Peyser PA, Bielak LF, Post WS, Chang YP, Ryan KA, Miller M, Rumberger JA, Sheedy PF 2nd, Shelton J, O’Connell JR, Shuldiner AR, Mitchell BD.Arch Intern Med. 2010 Nov 8;170(20):1850-5.

Relation of aortic valve calcium detected by cardiac computed tomography to all-cause mortality.
Blaha MJ, Budoff MJ, Rivera JJ, Khan AN, Santos RD, Shaw LJ, Raggi P, Berman D, Rumberger JA, Blumenthal RS, Nasir K.Am J Cardiol. 2010 Dec 15;106(12):1787-91

Using noncontrast cardiac CT and coronary artery calcification measurements for cardiovascular risk assessment and management in asymptomatic adults.
Rumberger JA. Vasc Health Risk Manag. 2010 Aug 9;6:579-91. Review.

Is it a Monet or a Picasso? The problems with “close up” plaque quantitation using MDCT.
Fein DA, Rumberger J. J Cardiovasc Comput Tomogr. 2010 Mar-Apr;4(2):116-8

Outcome of coronary plaque burden: a 10-year follow-up of aggressive medical management.
Goh VK, Lau CP, Mohlenkamp S, Rumberger JA, Achenbach S, Budoff MJ. Cardiovasc Ultrasound. 2010 Mar 12;8:5

Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality.
Santos RD, Rumberger JA, Budoff MJ, Shaw LJ, Orakzai SH, Berman D, Raggi P, Blumenthal RS, Nasir K. Atherosclerosis. 2010 Mar;209(1):131-5

Changing perceptions of hunger on a high nutrient density diet.
Fuhrman J, Sarter B, Glaser D, Acocella S Sarter B, Glaser D, Acocella S  Nutrition Journal. 2010 Nov 7;9:51

Fueling the vegetarian (vegan) athlete.
Fuhrman J, Ferreri DM.  Current Sports Medicine Reports. 2010 Jul-Aug;9(4):233-41

Absence of coronary artery calcification and all-cause mortality.
Blaha M, Budoff MJ, Shaw LJ, Khosa F, Rumberger JA, Berman D, Callister T, Raggi P, Blumenthal RS, Nasir K. JACC Cardiovasc Imaging. 2009 Jun;2(6):692-700.

Practical tips and tricks in cardiovascular computed tomography: non-contrast “heartscans”–beyond the calcium score.
Rumberger JA. J Cardiovasc Comput Tomogr. 2009 Jan-Feb;3(1):52-6

Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk.
Bielak LF, Horenstein RB, Ryan KA, Sheedy PF, Rumberger JA, Tanner K, Post W, Mitchell BD, Shuldiner AR, Peyser PA. Clin Med Cardiol. 2009 May 27;3:53-60

Coronary computed tomography angiography: our time has come, but there are miles to go before we sleep.
Rumberger JA. J Am Coll Cardiol. 2008 Nov 18;52(21):1733-5

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults.
Rampersaud E, Bielak LF, Parsa A, Shen H, Post W, Ryan KA, Donnelly P, Rumberger JA, Sheedy PF 2nd, Peyser PA, Shuldiner AR, Mitchell BD. Am J Epidemiol. 2008 Nov 1;168(9):1016-23

Coronary artery calcium scanning using computed tomography: clinical recommendations for cardiac risk assessment and treatment.
Rumberger JA.Semin Ultrasound CT MR. 2008 Jun;29(3):223-9. Review.

Role of noninvasive imaging using computed tomography for detection and quantification of coronary atherosclerosis.
Rumberger JA. Future Cardiol. 2008 May;4(3):269-83

The ethnic Rosetta stone: translating risk factors, plaque scores, and mortality.
Rumberger JA. J Am Coll Cardiol. 2007 Sep 4;50(10):961-3. Epub 2007 Aug 20

Gender differences in coronary arteries and thoracic aorta calcification.
Nasir K, Roguin A, Sarwar A, Rumberger JA, Blumenthal RS.
Arterioscler Thromb Vasc Biol. 2007 May;27(5):1220-2

Relationship between vascular calcification and bone mineral density in the Old-order Amish.
Shen H, Bielak LF, Streeten EA, Ryan KA, Rumberger JA, Sheedy PF 2nd, Shuldiner AR, Peyser PA, Mitchell BD.Calcif Tissue Int. 2007 Apr;80(4):244-50

Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles.
Bielak LF, Yu P, Ryan KA, Rumberger JA, Sheedy PF 2nd, Turner ST, Post W, Shuldiner AR, Mitchell BD, Peyser PA. Atherosclerosis. 2008 Feb;196(2):888-95

Determinants of coronary artery and aortic calcification in the Old Order Amish.
Post W, Bielak LF, Ryan KA, Cheng YC, Shen H, Rumberger JA, Sheedy PF 2nd, Shuldiner AR, Peyser PA, Mitchell BD.Circulation. 2007 Feb 13;115(6):717-24

Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.
Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M. Nutr Res. 2011 Aug;31(8):608-15.

Practical tips and tricks in cardiovascular computed tomography: non-contrast “heartscans”–beyond the calcium score.
Rumberger JA. J Cardiovasc Comput Tomogr. 2009 Jan-Feb;3(1):52-6

Coronary artery calcium scanning using computed tomography: clinical recommendations for cardiac risk assessment and treatment.
Rumberger JA. Semin Ultrasound CT MR. 2008 Jun;29(3):223-9. Review

“Interventional lipidology”: tomographic plaque imaging and aggressive treatment of metabolic disorders.
Hecht HS. Am J Cardiol. 2002 Aug 1;90(3):268-70

Relation of response of subclinical atherosclerosis detected by electron beam tomography to baseline low-density lipoprotein cholesterol levels.
Hecht HS, Harman SM.Am J Cardiol. 2004 Jan 1;93(1):101-3.PMID:14697479

Atherosclerotic risk factors revisited.
Hecht HS.Am J Cardiol. 2004 Jan 1;93(1):73-5. No abstract available. PMID:14697470

Translating tomographic plaque imaging into treatment: interventional lipidology.
Hecht HS. Prog Cardiovasc Dis. 2003 Sep-Oct;46(2):149-70. Review. PMID:14505289

Relation of aggressiveness of lipid-lowering treatment to changes in calcified plaque burden by electron beam tomography.
Hecht HS, Harman SM.Am J Cardiol. 2003 Aug 1;92(3):334-6. PMID:12888149

Evaluation by electron beam tomography of changes in calcified coronary plaque in treated and untreated asymptomatic patients and relation to serum lipid levels.
Hecht HS, Harman SM. Am J Cardiol. 2003 May 1;91(9):1131-4. No abstract available. PMID:12714164

Comparison of effectiveness of statin monotherapy versus statin and niacin combination therapy in primary prevention and effects on calcified plaque burden.
Hecht HS, Harman SM. Am J Cardiol. 2003 Feb 1;91(3):348-51. No abstract available.  PMID:12565097

Comparison of the effects of atorvastatin versus simvastatin on subclinical atherosclerosis in primary preventionas determined by electronbeam tomography.
Hecht HS, Harman SM.Am J Cardiol. 2003 Jan 1;91(1):42-5. PMID:12505569

“Interventional lipidology”: tomographic plaque imaging and aggressive treatment of metabolic disorders.
Hecht HS. Am J Cardiol. 2002 Aug 1;90(3):268-70. No abstract available.  PMID:12127614

Recommendations for preparticipation screening and the assessment of cardiovascular disease in masters athletes.
Hecht HS.Circulation. 2001 Sep 11;104(11):E58. No abstract available.  PMID:11551892

Impact of plaque imaging by electron beam tomography on the treatment of dyslipidemias.
Hecht HS. Am J Cardiol. 2001 Aug 15;88(4):406-8. No abstract available.PMID:11545763

New developments in atherosclerosis imaging: electron beam tomography.
Hecht HS. Curr Atheroscler Rep. 2001 Sep;3(5):417-24. Review.PMID: 11487453

Brief case reports of medically supervised, water-only fasting associated with remission of autoimmune disease.
Fuhrman J, Sarter B, Calabro DJ  Alternative Therapies in Health and Medicine. 2002 Jul-Aug;8(4):112, 110-1

A shoulder-facial synkinesis in normal human subjects.
Fuhrman J, Selzer ME, Kaplan FS.   University of Pennsylvania Orthopaedic Journal. 1991;7:43-45

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