By Donna Hayek, RD
Berberine health benefits continue to be studied for their potential role in supporting several areas of health. Berberine is a compound found in many plants, such as goldenseal, goldenthread, Oregon grape, barberry and tree turmeric.
Ongoing research suggests that berberine may support a variety of health conditions, including:
- Blood sugar control by helping the body respond better to insulin and reducing glucose production in the liver
- Blood pressure control, which may help lower the risk of stroke and heart disease
- PCOS by helping manage cholesterol levels, insulin resistance, and supporting weight management
- Heart health by helping reduce fatigue and certain arrhythmias
- Gut health by targeting harmful bacteria while supporting beneficial gut bacteria
- Inflammation by reducing oxidative stress, lowering inflammatory protein production, and promoting immune regulation
- Brain health by helping protect against brain damage and supporting cognitive function
There have also been early studies exploring berberine’s role in weight management, including reductions in BMI, though this research is still emerging.
Berberine affects several enzymes in the body, binding to them and altering how they function. It can be taken as a supplement; however, it is not regulated by the FDA. Typical dosing ranges from 250–500 mg per day, though individual needs may vary.
This supplement should not be used during pregnancy or prior to surgery. Berberine may interact with certain medications, so it is important to discuss its use with your healthcare provider before starting it. Potential side effects include digestive symptoms such as constipation or diarrhea, excessive lowering of blood pressure, and interference with how the liver metabolizes certain prescription medications, which may reduce their effectiveness.